normethadone

Normethadone is a synthetic opioid analgesic and antitussive agent. It acts primarily as an agonist at central opioid receptors in the medulla to suppress the cough reflex and likely also activates peripheral opioid receptors to inhibit signaling by irritant receptors of the airway. Normethadone is used for the treatment of cough when other less potent treatments have failed and has been marketed in combination with oxilofrine under brand names such as Cophylac. It is significantly more potent than morphine (12–20 times) and has a long duration of action (elimination half-life about 14 days). The drug is classified as an opioid analgesic and antitussive agent[1][2][7].

Brand names

CophylacTicardaDacartilEucoponMepidonNoramidoneNormedon

Other names

normethadonedesmethylmethadonephenyldimazone