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Drug intelligence / Profile preview
norpsilocin
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Subcutaneous, Oral, Sublingual, Buccal, Topical, Inhalation, Intravenous, Intramuscular, Transdermal, Intranasal
01
Overview
**Norpsilocin** is a tryptamine alkaloid (C11H14N2O, MW 190.24 g/mol) identified in 2017 in the hallucinogenic mushroom *Psilocybe cubensis*, where it occurs naturally and has been reported as a potential dephosphorylated metabolite of baeocystin. It acts as a near-full **agonist at the 5-HT2A receptor**, exhibiting higher potency than psilocin, with additional affinity for other serotonin receptors; it demonstrates good metabolic stability, blood-brain barrier penetration in animal models, and psychedelic properties associated with tryptamines.[1][5][7][8]
- Other names
- 4-hydroxy-N-methyltryptamine4-HO-NMT3-[2-(methylamino)ethyl]-1H-indol-4-ol
02
Targets
HTR1B (5-Hydroxytryptamine Receptor 1B)HTR2A (Serotonin receptor 5-HT2A)HTR2B (5-Hydroxytryptamine Receptor 2B)HTR2C (5-hydroxytryptamine 2C receptor)HTR7 (5-hydroxytryptamine receptor 7)HRH1 (Histamine H1 Receptor)SIGMAR1 (Sigma non-opioid intracellular receptor 1)TMEM97 (Sigma-2 receptor complex (TMEM97/PGRMC1))
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