norquetiapine

Norquetiapine is the major active metabolite of quetiapine, an atypical antipsychotic. It exhibits a distinctive pharmacological profile and is thought to contribute to the antidepressant and anxiolytic effects of quetiapine treatment. Mechanistically, norquetiapine acts as a potent inhibitor of the noradrenaline transporter (NET), a partial agonist at 5-HT1A (serotonin) receptors, and an antagonist at presynaptic alpha-2 adrenergic, 5-HT2C, and 5-HT7 receptors. It is also an antagonist at histamine H1, alpha-1 adrenergic, and muscarinic receptors. This broad spectrum of receptor affinities confers norquetiapine an antidepressant and anxiolytic pharmacological profile that is distinct from its parent compound[1][4].

Other names

N-desalkylquetiapine