NOTA-MNT-MSH

NOTA-MNT-MSH is a modular nanotransporter (MNT) conjugate designed for the targeted delivery of Auger electron-emitting radionuclides, specifically Indium-111 ($^{111}$In), to the nuclei of cancer cells overexpressing the melanocortin-1 receptor (MC1R). The MNT platform is an engineered recombinant polypeptide comprising four functional domains: an $\alpha$-melanocyte-stimulating hormone (MSH) ligand for receptor-specific binding and internalization, a diphtheria toxin translocation domain (tDTox) for endosomal escape, a nuclear localization sequence (NLS) for active nuclear transport, and a hemoglobin-like protein (HMP) acting as a carrier module. The NOTA (1,4,7-triazacyclononane-1,4,7-triacetic acid) moiety serves as a high-affinity chelator for the radionuclide. By facilitating the translocation of $^{111}$In from the cell surface to the nucleus, NOTA-MNT-MSH maximizes the cytotoxic potential of short-range Auger electrons against genomic DNA while minimizing damage to adjacent healthy tissues. It is primarily being investigated as a locally delivered radiotherapeutic for malignant melanoma and ocular melanoma.

Other names

111In-NOTA-MNT-MSHMC1R-targeted 111In-labeled MNTMC-1R-targeted 111In-labeled MNTMC 1R-targeted 111In-labeled MNTtDTox-HMP-NLS-MSH-NOTA