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Notch-2 siRNA
- Development stage
- Preclinical
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous, Intratumoral, Intraperitoneal, Subcutaneous
01
Overview
Notch-2 siRNA is a small interfering RNA (siRNA) designed to silence the expression of the Notch-2 receptor, a member of the Notch signaling pathway involved in cell growth, differentiation, and cancer progression. In preclinical research, particularly in bladder cancer, Notch-2 has been identified as a key driver of the invasive phenotype and epithelial-to-mesenchymal transition (EMT). By targeting and promoting the degradation of Notch-2 mRNA, this siRNA reduces the protein levels of the Notch-2 receptor, leading to decreased cell migration and alterations in the expression of genes associated with EMT and cell-cell adhesion. It is primarily utilized as a research tool to validate Notch-2 as a therapeutic target in oncology.
- Other names
- Notch2 siRNANotch-2 siRNANotch 2 siRNAsiRNA targeting Notch-2Notch-2 small interfering RNANotch2 small interfering RNANotch 2 small interfering RNA
02
Targets
NOTCH (Neurogenic locus notch homolog protein 3)
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