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notoginseng leaf
- Development stage
- Unknown
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Topical
01
Overview
Notoginseng leaf, derived from the dried leaves of *Panax notoginseng*, is a traditional Chinese medicinal herb and dietary supplement. It is rich in dammarane-type triterpenoid saponins (primarily protopanaxadiol-type saponins such as ginsenosides Rb3, Rb1, Rc, and Rd), flavonoids, and polysaccharides. It is traditionally used to nourish blood, improve blood circulation, disperse blood stasis, relieve pain, and reduce inflammation. Modern pharmacological studies have demonstrated that notoginseng leaf and its extracts possess neuroprotective, anti-inflammatory, antioxidant, and sedative-hypnotic properties, making it useful for treating insomnia, palpitations, anxiety, and ischemic stroke.
- Other names
- folium notoginsengnotoginseng leaf extractPanacis Notoginseng FoliumPanax notoginseng leafPanax notoginseng leaf extractPanax notoginseng leavesSanchi leafSanchi leaf extractSanqi leafSanqi leaf extractSanqi yeTian Qi YeTianqi ye
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)ESR1 (ERα)NMDAR (Glutamate receptor ionotropic, NMDA)NAMPTNPC1L1 (Niemann-pick C1-Like 1 transporter)PCSK9 (Proprotein convertase subtilisin/kexin type 9)TLR4 (Toll-like receptor 4)
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