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notoginsenoside Fe
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Notoginsenoside Fe is a minor dammarane-type triterpenoid saponin primarily isolated from the roots, leaves, and flowers of *Panax notoginseng* and *Panax japonicus*. It is frequently identified as a bioactive metabolite generated through the biotransformation of major ginsenosides, such as ginsenoside Rc, by gut microbiota or specific enzymatic processes. Research has highlighted its potential therapeutic utility in metabolic disorders, particularly obesity, where it has been shown to reduce food intake and body weight by activating energy-sensing neurons in the paraventricular nucleus (PVH) of the hypothalamus. Beyond its metabolic effects, notoginsenoside Fe exhibits anti-inflammatory, hemostatic, and anti-tumor activities. It has been studied for its ability to inhibit xanthine oxidase, making it a candidate for gout treatment, and for its inhibitory effects on lung adenocarcinoma cell proliferation. It is also a component of several traditional Chinese medicine (TCM) formulations investigated for acute lung injury and type 2 diabetes.
- Other names
- notoginsenoside FeN-Fe
02
Targets
CASP3 (Caspase-3)JUN (Transcription factor Jun)MMP9 (Matrix metalloproteinase-9)STAT3 (Signal Transducer and Activator of Transcription 3)VEGFA (Vascular endothelial growth factor A)XO (Xanthine Oxidoreductase)
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