NOX-B11-2

NOX-B11-2 is a Spiegelmer—a synthetic L-RNA oligonucleotide designed to bind and neutralize the peptide hormone ghrelin. Ghrelin is the endogenous ligand of the growth hormone secretagogue receptor 1a and is a key regulator of growth hormone release, appetite, and adiposity. NOX-B11-2 binds specifically to ghrelin, preventing its interaction with its receptor and thereby blocking ghrelin-induced food intake and neuronal activation in the arcuate nucleus. Preclinical studies show that NOX-B11-2 decreases food intake, reduces body weight, and fat mass in rodent models of obesity by neutralizing circulating ghrelin. The drug is administered subcutaneously and acts peripherally; it does not penetrate the central nervous system. The approach is under investigation as a potential therapy for obesity and conditions associated with hyperghrelinemia, such as Prader-Willi syndrome[3][4][5][7][9].

Other names

Spiegelmer NOX-B11-2anti-ghrelin Spiegelmer