Drug intelligence / Profile preview

noxytiolin

Development stage
Unknown
Lead developer
Geistlich Pharma
Modality
Nucleic Acid-Directed Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Irrigation, Topical, Intravesical, Intraperitoneal
01

Overview

Noxytiolin is a local antibacterial and antimicrobial agent primarily used for the therapeutic irrigation of infected body cavities, such as the bladder and peritoneum, and as a spray for burns. Its mechanism of action is believed to involve decomposition in aqueous solution to release formaldehyde, which provides its antimicrobial effect. Noxytiolin belongs to the class of thioureas (organosulfur compounds) and is typically administered as an irrigation solution at concentrations between 1–2.5%. It has also been shown in vitro to inhibit thyroid hormone synthesis by interfering with iodide organification in thyrocytes[6][8].

Brand names
Noxyflex-S
Other names
noxythiolin

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