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NPM-159 is a synthetic peptide drug candidate under preclinical development by Vivani Medical for the treatment of nonalcoholic steatohepatitis (NASH). The mechanism of action is as an agonist of the glucagon-like peptide 1 receptor (GLP-1R), which is a well-validated target in the metabolic disease space. Peptide activation of GLP-1R is designed to improve insulin secretion, suppress appetite, and reduce hepatic steatosis.
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