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NRICM102

Development stage: Phase 2
Lead developer: National Research Institute of Chinese Medicine
Modality: Small Molecules
Administration: Oral

Overview

NRICM102 is a multi-herbal traditional Chinese medicine (TCM) formulation developed by the National Research Institute of Chinese Medicine (NRICM) in Taiwan. Originally designed as a therapeutic for COVID-19, it has been investigated for its potential in treating chronic obstructive pulmonary disease (COPD) and other inflammatory lung injuries. The formula acts as an immunomodulator and anti-inflammatory agent, demonstrating the ability to improve pulmonary function, preserve lung architecture, and reduce the expression of key inflammatory markers including IL-1β, NLRP3, Muc5ac, and MMP12. It works by selectively modulating immune-related pathways, reversing COPD-associated gene expression patterns, and reducing cytokine signaling and chemokine activity.

Other names: Qingguan No. 2

Targets

NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)IL1B (Interleukin-1 beta)

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