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NRT-FX_01

Development stage: Preclinical
Lead developer: NEORNAT
Modality: Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
Administration: Parenteral

Overview

NRT-FX_01 is a preclinical antisense oligonucleotide (ASO) developed by NEORNAT for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis. The drug functions as an antisense inhibitor of let-7i-5p microRNA (miRNA). By inhibiting let-7i-5p, NRT-FX_01 is designed to restore the expression of thrombospondin-1 (TSP1), which in turn modulates the CD47-SIRPα signaling axis. This mechanism aims to activate macrophage phagocytosis, facilitating the clearance of damaged cells and the resolution of hepatic fibrosis in chronic liver diseases.

Other names: NRT-FX

Targets

let-7i-5p (MicroRNA let-7i-5p)

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