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NRT-YHD_002

Development stage: Preclinical
Lead developer: NEORNAT
Modality: Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics

Overview

NRT-YHD_002 is a preclinical-stage antisense miRNA therapeutic being developed by NEORNAT for the treatment of lung cancer. The drug acts as an antisense inhibitor of let-7i-5p microRNA (miRNA). By inhibiting let-7i-5p, NRT-YHD_002 is designed to restore the expression and activity of Thrombospondin-1 (TSP1). TSP1 is a key regulator of the CD47-SIRPα signaling pathway; its restoration enhances macrophage-mediated phagocytosis of cancer cells, effectively acting as a checkpoint inhibitor to boost the innate immune response against tumors.

Targets

THBS1 (Thrombospondin-1)CD47 (Cluster of Differentiation 47)let-7i-5p (MicroRNA let-7i-5p)

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