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NRT-YHD_003

Development stage: Preclinical
Lead developer: NEORNAT
Modality: Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
Administration: Intravenous

Overview

NRT-YHD_003 is a preclinical-stage antisense microRNA (miRNA) therapeutic being developed by the South Korean biotechnology company NEORNAT (NeoRNAT) for the treatment of pancreatic cancer. Utilizing an antisense oligonucleotide (ASO) modality, NRT-YHD_003 is designed to selectively bind to and inhibit specific miRNAs that are overexpressed in pancreatic tumor tissues. These target miRNAs typically function as "oncomiRs" by downregulating tumor-suppressor genes; by neutralizing them, NRT-YHD_003 aims to restore the expression of these suppressors, thereby inhibiting tumor cell proliferation, migration, and survival. The asset is part of NEORNAT's broader pipeline of RNA-based therapies focused on oncology and other high-unmet-need indications.

Targets

THBS1 (Thrombospondin-1)

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