NS-398

NS-398 is a selective cyclooxygenase-2 (COX-2) inhibitor classified as a non-steroidal anti-inflammatory drug (NSAID). It was developed primarily for mechanistic studies of cyclooxygenases and has been widely used in research to investigate the role of COX enzymes in inflammation, pain, and cancer. NS-398 exhibits potent analgesic and antipyretic effects with minimal gastrointestinal toxicity compared to non-selective NSAIDs. Its mechanism involves selective inhibition of prostaglandin G/H synthase 2 (COX‑2), leading to reduced synthesis of pro-inflammatory prostaglandins. The compound is orally active, induces apoptosis in certain tumor cells, and has been explored for its neuroprotective properties[1][3][4][6].

Other names

N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamideCS-2231CS2231CS 2231