NS004

NS004 is a substituted benzimidazolone small molecule that acts as a potent activator of both large-conductance calcium-activated potassium (BK) channels and cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels. It was the first compound described to activate both normal and mutant CFTR-associated chloride channels, making it a significant tool in cystic fibrosis research. In electrophysiological studies, NS004 has been shown to increase whole-cell efflux currents sensitive to iberiotoxin or tetraethylammonium. Additionally, the compound has been investigated for its inhibitory effects on mitochondrial function in glioma cells. NS004 is primarily utilized as a pharmacological research tool and has not been advanced into clinical development for therapeutic use.

Other names

5-trifluoromethyl-1-(5-chloro-2-hydroxyphenyl)-1,3-dihydro-2H-benzimidazole-2-oneCAS 141797-92-4CAS141797-92-4CAS-141797-92-4