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NS19504
- Development stage
- Unknown
- Lead developer
- NeuroSearch
- Modality
- Small Molecules
- Administration
- Intraperitoneal
01
Overview
NS19504 is a small-molecule, selective activator of large-conductance calcium-activated potassium (BK, KCa1.1, MaxiK) channels. Originally developed by NeuroSearch, the compound acts as a positive allosteric modulator of the BK channel, left-shifting its voltage activation curve and increasing potassium efflux. In preclinical studies, NS19504 has demonstrated the ability to relax bladder smooth muscle and reduce spontaneous phasic contractions, suggesting potential utility in bladder overactivity and urinary incontinence. Additionally, research has shown that NS19504-mediated BK channel activation exerts neuroprotective and anti-inflammatory effects in astrocytes, indicating potential therapeutic relevance in neuromyelitis optica spectrum disorders (NMOSD).
- Other names
- 5-(4-bromobenzyl)-1,3-thiazol-2-amine5-(4-bromobenzyl)thiazol-2-amine5-[(4-bromophenyl)methyl]-1,3-thiazol-2-amineNS 19504NS19504NS-19504
02
Targets
KCNMA1 (Calcium-activated potassium channel subfamily M alpha member 1)
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