NSAID + nalbuphine + local anesthetic + TAP block

This is a multimodal analgesic regimen combining a non-steroidal anti-inflammatory drug (NSAID), the opioid agonist-antagonist nalbuphine, and a local anesthetic administered as part of a transversus abdominis plane (TAP) block. The combination is used to provide enhanced postoperative pain control following abdominal surgery. - **NSAIDs** inhibit cyclooxygenase enzymes (COX-1 and COX-2), reducing prostaglandin synthesis and thereby decreasing inflammation and pain. - **Nalbuphine** acts as an agonist at kappa opioid receptors and antagonist at mu opioid receptors, providing effective analgesia with reduced risk of typical opioid side effects such as respiratory depression or pruritus[3][5]. - **Local anesthetics** (e.g., bupivacaine or ropivacaine) block voltage-gated sodium channels on nerve fibers, inhibiting nerve impulse transmission to produce regional anesthesia[6][7]. The TAP block technique involves injecting the drug mixture into the fascial plane between the internal oblique and transversus abdominis muscles to target nerves supplying the anterior abdominal wall. This approach can reduce postoperative pain intensity, decrease additional analgesic requirements, minimize opioid-related adverse effects such as nausea/vomiting or respiratory depression[3][5], and improve recovery after abdominal surgery.

Other names

NSAID plus nalbuphine plus local anesthetic with TAP blockmultimodal analgesia with NSAID, nalbuphine, and local anesthetic in TAP block