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NSAID + nalbuphine + local anesthetic + TAP block (Egymedicalpedia)
- Development stage
- Unknown
- Lead developer
- Egymedicalpedia
- Modality
- Small Molecules
- Administration
- Intravenous, Subcutaneous, Percutaneous
01
Overview
NSAID + NALUFIN + local anesthetic + TAP Block refers to a multimodal analgesic protocol evaluated in clinical research for the management of postoperative pain following elective cesarean section. This regimen combines several pharmacological and regional anesthesia techniques: intravenous nalbuphine (marketed as Nalufin), which acts as a mixed opioid agonist-antagonist; local subcutaneous wound infiltration with a local anesthetic; and a Transversus Abdominis Plane (TAP) block, a regional anesthetic technique that targets the nerves of the anterior abdominal wall. Non-steroidal anti-inflammatory drugs (NSAIDs) are typically integrated into this protocol as rescue analgesia. The combination is designed to optimize pain control while potentially reducing the total opioid consumption and associated side effects in the postpartum period.
- Brand names
- Nalufin
- Other names
- Comparative Study Between Transversus Abdominus Plain Block, Local Subcutaneous Injection in the Wound, and Intravenous Nalbuphine
02
Targets
KOR (Kappa opioid receptor)PGHS-1 (Prostaglandin G/H Synthase 1)MOR (Mu opioid receptor)Peripheral voltage-gated sodium channels
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