Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
NSC232003
- Development stage
- Preclinical
- Lead developer
- Inserm
- Modality
- Small Molecules
01
Overview
NSC232003 is a small molecule inhibitor of Ubiquitin-like with PHD and RING finger domains 1 (UHRF1), an epigenetic regulator that plays a key role in maintaining DNA methylation. NSC232003 binds to the 5-methylcytosine (5mC) binding pocket of the SRA domain of UHRF1, disrupting the interaction between UHRF1 and DNA methyltransferase 1 (DNMT1). This disruption leads to global DNA demethylation and the reactivation of tumor suppressor genes. Preclinical studies have investigated NSC232003 for its anticancer activity in various malignancies, including glioma and bladder cancer, as well as its potential to enhance immunotherapy responsiveness in autosomal dominant polycystic kidney disease (ADPKD) by remodeling the immunosuppressive microenvironment.
- Other names
- (5Z)-5-[1-(hydroxyamino)ethylidene]-2,3,4,5-tetrahydropyrimidine-2,4-dioneCAS 1905453-18-0CAS1905453-18-0CAS-1905453-18-0
02
Targets
UHRF1 (Ubiquitin-like with PHD and ring finger domains 1)
Beyond the preview
Go deeper on NSC232003.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on NSC232003.