NSC668394

NSC668394 is a small molecule inhibitor of Radixin (RDX), a member of the Ezrin-Radixin-Moesin (ERM) protein family. ERM proteins act as cross-linkers between the plasma membrane and the actin cytoskeleton, playing crucial roles in cell shape, motility, and signal transduction. In the context of oncology, NSC668394 has been shown to suppress the migration and proliferation of astrocytoma cells and microglia by down-regulating F-actin and inhibiting RDX-mediated chemoattraction. Research indicates its potential in controlling tumor growth and invasiveness by regulating the infiltration of tumor-associated microglia in the brain tumor microenvironment, particularly in Glioblastoma Multiforme (GBM) and low-grade glioma (LGG).