NSL-043

NSL-043 is a small molecule sirtuin 1 (SIRT1) activator being investigated for its neuroprotective properties in the treatment of neurodegenerative diseases and ischemic stroke. By selectively enhancing the deacetylation activity of the SIRT1 enzyme, NSL-043 promotes pathways that reduce neuroinflammation, mitigate oxidative stress, and improve mitochondrial function. In preclinical models, the compound has demonstrated the ability to protect neurons from amyloid-beta-induced toxicity and ischemic damage, suggesting potential therapeutic utility in conditions such as Alzheimer's disease. NSL-043 aims to slow disease progression by restoring cellular homeostasis and enhancing stress response mechanisms within the central nervous system.