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NSP-1047
- Development stage
- Preclinical
- Lead developer
- Novostar Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
NSP-1047 is a potent, small molecule inhibitor of MAPK-interacting kinases 1 and 2 (MNK1 and MNK2) developed by Novostar Pharmaceuticals. It functions by blocking the phosphorylation of eukaryotic initiation factor 4E (eIF4E), a key regulator of protein translation that is often dysregulated in cancer. By inhibiting the MNK/eIF4E axis, NSP-1047 suppresses the synthesis of tumorigenic proteins and modulates the expression of immune checkpoint proteins (PD-1, Tim-3, Lag-3) and inflammatory cytokines (IL-6, IL-8, IL-10). Preclinical data in acute myeloid leukemia (AML) models show potent antitumor activity and tumor regression, supported by favorable ADME and pharmacokinetic profiles.
02
Targets
MKNK2 (MAP kinase-interacting serine/threonine-protein kinase 2)MKNK1 (Mitogen‑activated protein kinase‑interacting serine/threonine-protein kinase 1)
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