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NSupple_Silybum is a silymarin-enriched nutraceutical blend developed for the management of obesity, metabolic syndrome, and associated inflammation. The formulation combines prebiotics (fructooligosaccharides, galactooligosaccharides, and yeast β-glucans), essential minerals (magnesium, selenium, and zinc), and silymarin (an extract from *Silybum marianum*). It functions primarily by reshaping the gut microbiota, increasing the abundance of beneficial species such as *Faecalibacterium prausnitzii* and *Lactobacillus*, and improving the Firmicutes/Bacteroidetes ratio. Clinical studies in overweight and obese adults have demonstrated that NSupple_Silybum supplementation leads to significant reductions in body weight, waist-to-height ratio, total cholesterol, and pro-inflammatory markers like the TNF-α/IL-10 ratio, while also improving sleep quality and reducing cortisol levels.
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