NT69L

NT69L is a synthetic hexapeptide analog of the neurotensin (8-13) fragment that acts as a potent and nonselective agonist at neurotensin receptors NTS1 and NTS2. NT69L exhibits atypical antipsychotic-like properties in animal models, including the ability to block disruptions of prepulse inhibition and hyperactivity induced by psychostimulants such as amphetamine and DOI, effects consistent with antipsychotic agents. NT69L also increases dopamine and acetylcholine efflux in the medial prefrontal cortex and can block reinstatement of cocaine preference, supporting research into its utility for schizophrenia, psychosis, and substance use disorders[1][2][3][5][6].