NU9056

**NU9056** is a potent and selective small-molecule inhibitor of **KAT5** (also known as Tip60), a member of the MYST family of histone acetyltransferases that regulates chromatin remodeling, gene transcription, and DNA damage response[7][8][10]. NU9056 was developed as a cell-permeable compound with high selectivity for KAT5 (IC50 ≈ 2 µM) and minimal activity against other acetyltransferases such as p300, pCAF, and GCN5[7][10]. It inhibits histone acetylation and (in preclinical studies) impairs DNA damage response, reduces protein acetylation, induces apoptosis in various cancer cell lines, and suppresses proliferation and tumor growth in mouse models[8][10]. NU9056 has shown promising effects in preclinical models of prostate cancer, anaplastic thyroid carcinoma, ocular inflammation, and sepsis-associated encephalopathy, acting primarily by blocking KAT5 activity and downstream pathways such as NLRP3 inflammasome activation, c-Myc regulation, and microglial inflammatory responses[1][3][4][8]. It is primarily used as a research tool compound and is not approved for clinical use.

Other names

NU9056NU-9056NU 9056