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Nuan Gan Hua Zhuo

Development stage: Preclinical
Administration: Oral

Overview

Nuan Gan Hua Zhuo is a traditional Chinese medicine (TCM) herbal formula, also referred to as the "Nuan Gan Hua Zhuo recipe." It is used in TCM practice for syndromes related to liver function and is typically prescribed for conditions involving liver Qi stagnation, cold accumulation, or dampness obstructing the liver channel. The formula consists of multiple herbs combined according to TCM principles; however, the exact composition may vary by practitioner or clinical trial. Its mechanism of action is based on harmonizing and warming the liver, dispelling cold and dampness, promoting Qi circulation, and resolving stasis. There are no well-documented modern pharmacological mechanisms or single molecular targets established for this formula in Western medicine.

Other names: Nuan Gan Hua Zhuo recipe

Targets

mTOR (Mammalian target of rapamycin kinase)EPHX2 (Soluble epoxide hydrolase)LTA4H (Leukotriene A4 hydrolase)MEK1 (Dual specificity mitogen-activated protein kinase kinase 1)STAT3 (Signal Transducer and Activator of Transcription 3)DGAT1 (Diacylglycerol O-acyltransferase 1)

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