Drug intelligence / Profile preview

nux vomica

Development stage
Phase 4
Modality
Small Molecules
Administration
Oral, Sublingual
01

Overview

Nux vomica is a natural product derived from the seeds of the Strychnos nux-vomica tree, native to India and Southeast Asia. The seeds contain potent alkaloids—primarily strychnine and brucine—which are highly toxic. In traditional medicine systems such as Ayurveda and Unani, as well as in homeopathy, nux vomica has been used for a wide range of conditions including digestive complaints (constipation, indigestion), headaches and migraines, stress-related symptoms (anxiety, irritability), insomnia, menstrual problems, back pain, male infertility/impotence and hangovers[1][3][4][6][8]. However, there is no robust scientific evidence supporting its efficacy for these uses[1][3][4]. The mechanism of action is primarily due to strychnine’s effect on the central nervous system; it acts as an antagonist at glycine receptors in the spinal cord and brainstem. This leads to increased neuronal excitability resulting in muscle contractions that can progress to convulsions or death at higher doses[1]. Homeopathic preparations are extremely diluted but products containing measurable amounts of seed extract are considered unsafe due to toxicity risks. Nux vomica is banned or severely restricted in many countries because even small amounts can cause severe side effects including restlessness, anxiety, dizziness, muscle stiffness/spasms (notably jaw/neck), seizures/convulsions respiratory failure or death[1][2][3].

Brand names
Hyland's NUX VOMICABoiron Nux Vomica
Other names
Strychnos nux-vomicapoison nutvomiting nutquaker buttonssemen strychnos
02

Targets

Glycine receptor

Beyond the preview

Go deeper on nux vomica.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on nux vomica.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call