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NW-L-123LA

Development stage: Preclinical
Lead developer: Newave Pharmaceutical
Modality: Small Molecules

Overview

NW-L-123LA is a preclinical-stage small molecule inhibitor targeting B-cell lymphoma 2 (Bcl-2), developed by Newave Pharmaceutical. Bcl-2 is an anti-apoptotic protein often overexpressed in various hematological malignancies, where it prevents programmed cell death. By inhibiting Bcl-2, NW-L-123LA aims to restore apoptotic pathways in malignant cells. It is currently being investigated for the treatment of relapsed or refractory (R/R) B-cell malignancies and is distinct from Newave's other Bcl-2 inhibitor, lazclatinib (LP-100), which is in clinical development.

Targets

BCL-2 (BCL-2 family)

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