Drug intelligence / Profile preview

NWPT-SM32300

Development stage
Unknown
Lead developer
NW PharmaTech
Modality
Small Molecules
Administration
Oral
01

Overview

NWPT-SM32300 is an investigational, pharmaceutical-grade oral cannabidiol (CBD) formulation developed by NW-Pharmatech. It utilizes a high-loading micellar delivery system formulated as a softgel capsule to improve the oral bioavailability and absorption consistency of CBD. NWPT-SM32300 is under clinical development as a monotherapy for the treatment of acute schizophrenia and clinical high risk for psychosis (CHR-P). Unlike traditional antipsychotics that primarily target dopamine D2 receptors, CBD acts through a multi-target mechanism of action, including negative allosteric modulation of cannabinoid receptors (CB1 and CB2), agonism of serotonin 5-HT1A and TRPV1 receptors, antagonism of GPR55, and inhibition of fatty acid amide hydrolase (FAAH) to enhance endocannabinoid signaling.

Other names
CBDcannabidiol
02

Targets

CNR1 (Cannabinoid receptor 1)GPR55 (G protein-coupled receptor 55)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))TRPV1 (Transient receptor potential cation channel subfamily V member 1)FAAH

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