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Drug intelligence / Profile preview
NWPT-SM32300
- Development stage
- Phase 1
- Lead developer
- NW PharmaTech
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
NWPT-SM32300 is an investigational, pharmaceutical-grade oral cannabidiol (CBD) formulation developed by NW-Pharmatech. It utilizes a high-loading micellar delivery system formulated as a softgel capsule to improve the oral bioavailability and absorption consistency of CBD. NWPT-SM32300 is under clinical development as a monotherapy for the treatment of acute schizophrenia and clinical high risk for psychosis (CHR-P). Unlike traditional antipsychotics that primarily target dopamine D2 receptors, CBD acts through a multi-target mechanism of action, including negative allosteric modulation of cannabinoid receptors (CB1 and CB2), agonism of serotonin 5-HT1A and TRPV1 receptors, antagonism of GPR55, and inhibition of fatty acid amide hydrolase (FAAH) to enhance endocannabinoid signaling.
- Other names
- CBDcannabidiol
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))CNR1 (Cannabinoid receptor 1)FAAHGPR55 (G protein-coupled receptor 55)TRPV1 (Transient receptor potential cation channel subfamily V member 1)
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