nx210c

NX210c is a synthetic, cyclic 12-amino-acid peptide derived from the most conserved sequence of the type 1 thrombospondin repeats of subcommissural organ-spondin (SCO-spondin). It is designed to mimic neuroprotective and neuroregenerative properties associated with SCO-spondin, which plays a key role in neuronal development and repair. The cyclic form (NX210c) is created by a disulfide bond between two cysteines. Mechanistically, NX210c exerts its effects via integrin receptors and γ-secretase substrates, activating the PI3K/Akt/mTOR pro-survival pathway and disrupting apoptotic cascades. Preclinical studies show that it strengthens blood-brain barrier integrity by increasing tight junction proteins such as claudin-5 and occludin, reducing permeability, and improving transendothelial electrical resistance. It has demonstrated beneficial effects in animal models of neurological disorders including Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Parkinson’s disease, multiple sclerosis (MS), spinal cord injury, and cerebrovascular disorders[1][4][5][6][8]. Clinical development is ongoing for several CNS indications.

Other names

l-tryptophanyl-l-seryl-glycyl-l-tryptophanyl-l-seryl-l-seryl-l-cysteinyl-l-seryl-l-arginyl-l-seryl-l-cysteinyl-glycyl (disulfide bond), acetate saltWSGWSSCSRSCGNX-210cNX210cNX 210c