Drug intelligence / Profile preview

NXT15906F6

Development stage
Unknown
Lead developer
NXT USA
Modality
Small Molecules
Administration
Oral
01

Overview

NXT15906F6 (TamaFlex) is a proprietary botanical combination consisting of standardized extracts from *Tamarindus indica* (tamarind) seeds and *Curcuma longa* (turmeric) rhizomes. It is developed as a synergistic formulation to support joint health and mitigate symptoms of osteoarthritis. Clinical studies have demonstrated that NXT15906F6 significantly reduces knee joint pain and improves musculoskeletal function and joint motility, with effects observed as early as five days after initiation. Its mechanism of action involves anti-inflammatory activity, evidenced by the reduction of systemic inflammatory markers like high-sensitivity C-reactive protein (hs-CRP), and chondroprotective effects, indicated by the reduction of the cartilage degradation marker C-terminal telopeptide of type II collagen (uCTX-II). It is primarily marketed as a dietary supplement for joint comfort and mobility.

Brand names
TamaFlex
Other names
Tamarindus indica seed extract + Curcuma longa rhizome extract
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)TNFA (Tumor necrosis factor alpha (soluble))ALOX12 (Arachidonate 12-lipoxygenase, 12S type)

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