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NY-ESO-1(157-165) peptide-pulsed autologous dendritic cell vaccine
- Development stage
- Unknown
- Lead developer
- UCLA Jonsson Comprehensive Cancer Center
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Intravenous, Subcutaneous, Intradermal, Intranodal
01
Overview
A personalized, investigational cancer immunotherapy composed of a patient's own (autologous) dendritic cells that have been pulsed ex vivo with a synthetic peptide derived from the NY‑ESO‑1 tumor-associated antigen (specifically amino acids 157–165). NY‑ESO‑1 is a cancer-testis antigen expressed in various tumors and minimally in normal tissues except for testes. The therapy aims to stimulate an immune response—primarily cytotoxic T lymphocyte activation—against NY‑ESO‑1-expressing tumor cells. This approach is being studied mainly for malignant solid tumors and cancers, including sarcoma and neuroblastoma, with clinical trials reaching up to phase 2[2][3][8]. The mechanism involves enhanced presentation of the NY‑ESO‑1 epitope by patient-derived dendritic cells to T-cells, promoting targeted anti-tumor immunity.
- Other names
- ny-eso-1(157–165) peptide-pulsed dc vaccineny-eso-1(157–165)-pulsed dendritic cell vaccineny‑eso‑1 157–165 peptide pulsed dendritic cells
02
Targets
HLA-A*02 (Human leukocyte antigen A*02 complexed peptide)pMHC-I (Peptide–MHC class I complex)
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