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ny-eso-1 peptide-pulsed dendritic cells
- Development stage
- Unknown
- Lead developer
- UCLA Jonsson Comprehensive Cancer Center
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Intradermal, Subcutaneous, Intravenous
01
Overview
NY-ESO-1 peptide-pulsed dendritic cells are an autologous cellular immunotherapy and cancer vaccine designed to elicit a targeted immune response against tumors expressing the New York esophageal squamous cell carcinoma 1 (NY-ESO-1) antigen. The process involves harvesting a patient's monocytes via leukapheresis, differentiating them into dendritic cells (DCs) ex vivo, and "pulsing" or loading them with specific HLA-restricted peptides derived from the NY-ESO-1 protein. NY-ESO-1 is a cancer-testis antigen that is highly expressed in various malignancies—including melanoma, synovial sarcoma, and ovarian cancer—but is absent in normal adult tissues except for the testis, making it a highly specific target. Once re-infused into the patient, these mature, antigen-presenting DCs migrate to the lymph nodes where they activate and expand NY-ESO-1-specific CD8+ cytotoxic T lymphocytes and CD4+ helper T cells to recognize and destroy tumor cells.
- Other names
- NY-ESO-1 pulsed DC vaccineNY-ESO1 pulsed DC vaccineNY-ESO 1 pulsed DC vaccineNY-ESO-1 peptide-loaded dendritic cellsNY-ESO1 peptide-loaded dendritic cellsNY-ESO 1 peptide-loaded dendritic cellsNY-ESO-1-pulsed autologous dendritic cell vaccineNY-ESO1-pulsed autologous dendritic cell vaccineNY-ESO 1-pulsed autologous dendritic cell vaccine
02
Targets
New York esophageal squamous cell carcinoma 1 (NY-ESO-1) peptide-HLA complex
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