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nypa fruticans ethyl acetate leaf extract
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Nypa fruticans ethyl acetate leaf extract (EaNFL) is a botanical extract derived from the leaves of the Nypa palm (*Nypa fruticans*). It contains a variety of bioactive polyphenolic compounds, including rosmarinic acid, quercetin, and (-)-epicatechin. Research indicates that EaNFL possesses renoprotective, antioxidant, and anti-inflammatory properties. In preclinical models of gentamicin-induced nephrotoxicity, it has demonstrated the ability to improve renal function and reduce tubular necrosis and glomerular damage. Its mechanism of action involves the modulation of the renin-angiotensin-aldosterone system (RAAS) via the AT1 receptor and the inhibition of glucose transport through SGLT2, alongside the mitigation of oxidative stress and inflammation.
- Other names
- Nypa fruticans leaf extractEaNFL
02
Targets
SGLT2 (Sodium-glucose cotransporter protein subunit 2)AGTR1 (Angiotensin II Type-1 receptor)
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