nystatin + didanosine

**Nystatin + didanosine** is a fixed-dose combination of two pharmaceuticals: **nystatin**, an antifungal polyene macrolide, and **didanosine**, a nucleoside reverse transcriptase inhibitor (NRTI). - **Nystatin** binds to ergosterol in the fungal cell membrane, forming pores that lead to leakage of cellular contents, and is primarily used for the treatment of Candida infections. - **Didanosine** is an antiretroviral drug that inhibits HIV-1 reverse transcriptase by acting as a chain terminator during viral DNA synthesis. This combination may be co-formulated to exploit nystatin’s antiviral/antifungal prophylactic effect in immunocompromised patients, such as those with HIV/AIDS treated with didanosine, to prevent oral or gastrointestinal candidiasis. However, no evidence in the provided search results indicates the existence of a unique approved product under this exact combination name, though both medicines are used in HIV/AIDS care.