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Drug intelligence / Profile preview
O-1918
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- In Vitro (research Use); No Established Clinical Route
01
Overview
O-1918 is a synthetic small molecule compound structurally related to cannabidiol. It acts as an antagonist at the G protein-coupled receptors GPR18 and GPR55, which are former orphan receptors now recognized as part of the extended endocannabinoid system. These receptors are implicated in mediating non-CB1 and non-CB2 cannabinoid effects. O-1918 is widely used in research to study the pharmacology of these atypical cannabinoid targets and their physiological roles. Additionally, electrophysiological studies have shown that O-1918 is a potent inhibitor of large-conductance calcium-dependent potassium (BKCa) channels[1][3][7]. There is interest in its potential for modulating vascular tone and energy metabolism.
- Other names
- 1,3-dimethoxy-5-methyl-2-((1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl)benzene
02
Targets
GPR18 (G protein-coupled receptor 18)GPR52 (G protein-coupled receptor 52)GPR55 (G protein-coupled receptor 55)KCNMA1 (Calcium-activated potassium channel subfamily M alpha member 1)
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