Drug intelligence / Profile preview

O-COX Gel

Development stage
Unknown
Lead developer
Captab Biotec
Modality
Small Molecules
Administration
Topical
01

Overview

O-COX Gel is a topical fixed-dose combination gel developed by Captab Biotec for the relief of pain and inflammation associated with musculoskeletal and orthopedic conditions, such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The formulation contains etoricoxib (1%), a highly selective cyclooxygenase-2 (COX-2) inhibitor that reduces prostaglandin synthesis to alleviate deep pain and swelling; methyl salicylate (10%) and menthol (5%), which act as counterirritants to produce synergistic cooling and warming sensations that distract from underlying pain; linseed oil (3%), which provides anti-inflammatory benefits and enhances dermal penetration; and benzyl alcohol (1%), which serves as a preservative with mild local anesthetic properties.

Brand names
O-COX Gel
Other names
Etoricoxib 1% + Methyl Salicylate 10% + Linseed Oil 3% + Menthol 5% + Benzyl Alcohol 1%etoricoxib + linseed oil + menthol + methyl salicylateetoricoxib + linseed oil + menthol + methyl salicylate + benzyl alcohol
02

Targets

PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)TRPA1 (Transient receptor potential cation channel subfamily A member 1)TRPM8 (Transient receptor potential cation channel subfamily M member 8)TRPV1 (Transient receptor potential cation channel subfamily V member 1)

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