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O-Genesis
- Development stage
- Unknown
- Lead developer
- O-Genesis
- Modality
- Hematopoietic Stem Cells → Adult Stem Cells → Stem Cell Therapies → Cell Therapies, Patient-derived iPSCs → iPSCs → Pluripotent Stem Cells → Stem Cell Therapies → Cell Therapies, Autologous CAR-T → CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Mesenchymal Stem Cells → Adult Stem Cells → Stem Cell Therapies → Cell Therapies, Tumor-Infiltrating Lymphocytes (TILs) → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous, Intraperitoneal
01
Overview
O-Genesis is an autologous cell therapy candidate developed for the treatment of Type 1 and Type 2 Diabetes. The therapy involves the extraction of a patient's own adipose-derived stem cells (ADSCs), which are then subjected to a proprietary ex vivo chemical reprogramming process to differentiate them into functional, insulin-producing cells (IPC). These cells are subsequently re-implanted into the patient, typically via the portal vein or into the omentum, where they are intended to sense blood glucose levels and secrete insulin in a physiologically appropriate manner. By restoring endogenous insulin production, O-Genesis aims to reduce or eliminate the dependency on exogenous insulin injections and improve long-term glycemic control.
- Brand names
- O-Genesis
- Other names
- Autologous adipose-derived insulin-producing cells
02
Targets
INSR (Insulin receptor)
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