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Drug intelligence / Profile preview
O-Glutarylpsilocin
- Development stage
- Preclinical
- Lead developer
- Reunion Neuroscience
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
O-Glutarylpsilocin (developmental code name RE109) is a serotonergic psychedelic of the tryptamine family. It acts as a prodrug of psilocin (4-HO-DMT), similar to other psilocin prodrugs like 4-AcO-DMT and psilocybin. After administration, it is cleaved by non-specific esterases to release active psilocin in the body. The compound was first described in scientific literature in 2024 and has been patented by Reunion Neuroscience for potential use as an antidepressant or for other neuropsychiatric indications[2][8].
- Other names
- 4-glutaryloxy-N,N-dimethyltryptamine4-HO-DMT O-glutarate
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR2A (Serotonin receptor 5-HT2A)HTR2C (5-hydroxytryptamine 2C receptor)
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