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o-Institut de Recherche pour le Developpement-malaria
- Development stage
- Unknown
- Lead developer
- Institut de Recherche pour le Développement
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- Small Molecules
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- Oral
01
Overview
o-Institut de Recherche pour le Developpement-malaria refers to the clinical research program and therapeutic regimens evaluated by the Institut de Recherche pour le Développement (IRD) for malaria prevention. Specifically, this designation encompasses the PACOME trial, a Phase 3 randomized controlled study conducted in Benin. The trial evaluated the efficacy and safety of daily cotrimoxazole prophylaxis (a combination of sulfamethoxazole and trimethoprim) compared to intermittent preventive treatment (IPTp) with mefloquine for the prevention of pregnancy-associated malaria in HIV-infected women. The research aimed to identify optimal prevention strategies for this high-risk population, as standard sulfadoxine-pyrimethamine IPTp is often contraindicated due to potential cross-reactivity with cotrimoxazole prophylaxis used for HIV management.
- Other names
- PACOME trial interventions
02
Targets
β-HematinDHFR (Dihydrofolate reductase)DHPS (Dihydropteroate synthase)
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