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oAdwtIL-18
- Development stage
- Preclinical
- Lead developer
- Nanjing University
- Modality
- Gene Silencing → Gene Therapies, Oncolytic Viruses → Oncolytic Therapeutics, Gene Editing → Gene Therapies, Gene Addition/Replacement → Gene Therapies
- Administration
- Intratumoral
01
Overview
oAdwtIL-18 is a preclinical-stage oncolytic adenovirus engineered to express wild-type interleukin-18 (wtIL-18). Developed by researchers at Nanjing University, this cytokine-armed oncolytic virus is designed to selectively replicate in and lyse cancer cells while locally delivering wtIL-18 to the tumor microenvironment. The virus features a modified adenovirus backbone with an Ad5/3 chimeric fiber to enhance tumor targeting and cell entry via desmoglein-2 (DSG2) and CD46, bypassing the need for the coxsackievirus-adenovirus receptor (CAR). Once expressed, wtIL-18 stimulates T helper 1 (Th1) and natural killer (NK) cells, promoting the production of interferon-gamma (IFN-γ) and enhancing antitumor immunity. In preclinical studies, oAdwtIL-18 has been evaluated in syngeneic mouse models of colorectal cancer, melanoma, and breast cancer, demonstrating significant tumor growth inhibition, although its efficacy is limited by the endogenous decoy receptor IL-18 binding protein (IL-18BP) compared to decoy-resistant variants like oAdDR18.
- Other names
- oAd-wtIL-18oAd-wtIL18oAd-wtIL 18oncolytic adenovirus encoding wild-type IL-18
02
Targets
CD46 (CD46 Molecule)DSG2 (Desmoglein-2)IL-18R (Interleukin-18 receptor complex)IL18BP (Interleukin-18 binding protein)
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