Drug intelligence / Profile preview

oat protein fibril-iron complex

Development stage
Preclinical
Lead developer
ETH Zurich
Modality
Nanoparticles → Drug Delivery Systems, Recombinant Proteins and Enzymes
Administration
Oral
01

Overview

**Oat protein fibril-iron complex** is an investigational, plant-based iron-delivery and food-fortification material consisting of edible oat protein nanofibrils coated with ultrasmall iron nanoparticles. The hybrid can be engineered to contain predominantly ferrous or ferric iron; the ferrous preparation generated using sodium ascorbate demonstrated substantially greater fractional iron absorption than ferrous sulfate in a prospective stable-isotope crossover study in 52 young women with iron deficiency, while the ferric preparation showed favorable sensory characteristics in reactive food matrices. It is being developed by ETH Zurich as a dietary iron supplement and food fortificant for iron deficiency and iron deficiency anemia, rather than as a conventional receptor-targeted pharmaceutical. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/41214296/))

Other names
oat protein fibril-iron complexoat protein nanofibril-iron hybridoat protein nanofibril-iron hybrids

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