obacunone

Obacunone is a natural limonoid triterpenoid found in various citrus fruits and medicinal plants, notably Dictamnus dasycarpus and Phellodendron amurense. It is recognized for its multiple pharmacological properties, including antioxidant, anti-inflammatory, antifungal, antitumor, anti-fibrotic, and potential metabolic disease-modulating effects. Obacunone acts as a potent agonist of NRF2 (Nuclear factor erythroid 2-related factor 2), a regulator of cellular antioxidant responses, and has also been identified as a histone deacetylase 1 inhibitor with downstream suppression of p38 MAPK signaling. The compound’s mechanisms are multi-target in nature, conferring cytoprotection from oxidative stress, inhibition of inflammation, reduction of fibrosis, and potential suppression of certain tumors. Obacunone is under preclinical or early development for a range of indications, including infections (antifungal and antiviral), acute lung injury, fibrotic diseases, metabolic disorders such as hypercholesterolemia and osteoporosis, and cancer[1][3][4][6][7].

Other names

CasimirolideObacunoic acid eta-lactoneOBACUNONCHEBI:7713