Obadex

Obadex is a combination ophthalmic pharmaceutical product marketed by SKT Healthcare. It consists of the aminoglycoside antibiotic tobramycin and the potent synthetic glucocorticoid dexamethasone. This combination is indicated for the treatment of steroid-responsive inflammatory ocular conditions where a bacterial infection or a risk of bacterial ocular infection exists, such as uveitis, eye injury, radiation-induced inflammation, or chemical burns. Tobramycin provides bactericidal activity by binding to the bacterial 30S ribosomal subunit, thereby inhibiting protein synthesis. Dexamethasone acts as a glucocorticoid receptor agonist to suppress the inflammatory response, reducing edema, capillary dilation, and fibrin deposition. The product is formulated as eye drops for topical ophthalmic administration.

Brand names

Obadex

Other names

tobramycin + dexamethasone