obestatin

Obestatin is a 23-amino acid peptide hormone derived from the post-translational cleavage of preproghrelin, the same precursor protein that yields ghrelin. First identified in 2005, obestatin was initially proposed to act as an appetite-suppressing (anorectic) counterpart to ghrelin, though its role in feeding behavior and its exact cognate receptor remain subjects of ongoing scientific debate. While early studies suggested that obestatin binds to and activates the G-protein coupled receptor GPR39, subsequent research has yielded conflicting results regarding this interaction. Beyond appetite regulation, obestatin has been investigated preclinically for its cytoprotective, anti-apoptotic, and proliferative effects on pancreatic beta-cells, islet endothelial cells, skeletal muscle, and cardiovascular tissues, showing potential therapeutic relevance in metabolic disorders, diabetes, and muscle wasting conditions.

Other names

human obestatinobestatin (human)