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Ocean Univ. of China SOS1 compound 23
- Development stage
- Unknown
- Lead developer
- Ocean University of China
- Modality
- PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules
01
Overview
Ocean Univ. of China SOS1 compound 23: sourced facts only. name: "Thus, we design, synthesize, and characterize a potent and specific SOS1 degrader 23." [PMID:38316747]; target: "Thus, we design, synthesize, and characterize a potent and specific SOS1 degrader 23." [PMID:38316747]; developer: "Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003, China." [PMID:38316747]; modality: "A Potent SOS1 PROTAC Degrader with Synergistic Efficacy in Combination with KRASG12C Inhibitor." [PMID:38316747]; stage: "Importantly, the combination of 23 with AMG510 suppressed RAS signaling feedback activation, showing synergistic effects against KRASG12C mutant cells in vitro and in vivo." [PMID:38316747]
02
Targets
SOS1 (Son of sevenless homolog 1)
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