ochromycinone

Ochromycinone, also widely known by the code name STA-21, is a natural angucyclinone antibiotic and a small molecule inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3) signaling pathway. Originally isolated from various *Streptomyces* species, such as *Streptomyces ochraceus*, it possesses a characteristic tetracyclic benz[a]anthracene skeleton. Ochromycinone functions by specifically binding to the SH2 domain of STAT3, which prevents its dimerization and subsequent DNA binding. This inhibition disrupts the expression of genes involved in cell proliferation, survival, and inflammation. Due to the critical role of STAT3 in the pathogenesis of inflammatory diseases and various malignancies, ochromycinone has been investigated for its therapeutic potential in treating psoriasis and certain cancers. Clinical research has included pilot studies evaluating its efficacy as a topical treatment for psoriatic lesions.

Other names

ochromycinoneSTA 21STA21STA-21(8R,9S)-8,9-dihydroxy-1-methyl-8,9-dihydrotetraphene-7,12-dione