Drug intelligence / Profile preview

ocimum gratissimum extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

Ocimum gratissimum extract is derived from the leaves of the plant Ocimum gratissimum, commonly known as clove basil or African basil. It contains a range of bioactive phytochemicals and essential oils, including oleanolic acid, caffeic acid, rosmarinic acid, luteolin, quercetin, eugenol, β-caryophyllene, linalool, and thymol. The extract has shown antioxidant, anti-inflammatory, anticancer, hepatoprotective, antidiabetic, antihypertensive, antidiarrheal, and antimicrobial activities in various in vitro and in vivo studies. Mechanistically, these effects are attributed to inhibition of matrix metalloproteinases, reduction of oxidative stress, modulation of apoptotic pathways (caspase-3, PARP, Bax/Bcl-2), and direct antimicrobial action, primarily due to constituents like eugenol. The extract is widely used in traditional medicine for the treatment of infections, inflammation, diabetes, cancer, and gastrointestinal disorders[1][3][4][6][7].

Other names
clove basil extractchayi-yaafrican basil extractO. gratissimum extract
02

Targets

15-LOX (Lysyl Oxidase)MMP9 (Matrix metalloproteinase-9)BCL-2 (BCL-2 family)Microbial lipid membraneCASP3 (Caspase-3)

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