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Drug intelligence / Profile preview
ocimum sanctum leaf extract
- Development stage
- Preclinical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Ocimum sanctum leaf extract, derived from the Holy Basil or Tulsi plant, is a botanical preparation rich in bioactive phytochemicals such as eugenol, caryophyllene, and ursolic acid. It is widely recognized in Ayurvedic medicine for its adaptogenic, anti-inflammatory, and antioxidant properties. The extract is primarily investigated for its ability to mitigate oxidative stress and inflammation by scavenging free radicals and enhancing the activity of endogenous antioxidant enzymes. In preclinical models of Chronic Obstructive Pulmonary Disease (COPD), it has demonstrated the potential to reduce lung injury and inflammation induced by cigarette smoke by upregulating enzymes like superoxide dismutase (SOD) and catalase. While commonly used as a dietary supplement for stress and general wellness, it is under exploration as a therapeutic option for inflammatory and respiratory conditions.
- Brand names
- TulsiHoly Basil
- Other names
- Holy Basil leaf extractTulsi leaf extractOcimum tenuiflorum leaf extracthydroethanolic leaf extract of Ocimum sanctum
02
Targets
NeuraminidaseGST (Glutathione S-transferase alpha 3)GPX4 (Glutathione peroxidase 4)GSR (Glutathione reductase)Misfolded SOD1
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